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203639

Polymorphism in Vitamin D Receptor Gene and Their Relation to Streptococcus mutans in Deciduous Teeth Decay among Egyptian Children

Article

Last updated: 23 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Multiple factors play a role in the dental decay occurrence, including microorganisms, diet, oral hygiene, medical conditions, and lack of important nutrients, such as vitamin D. Objectives: correlation between VDR gene and Streptococcus mutans count in children deciduous teeth decay. Methodology: Cross sectional study from January 2018 till January 2019. One hundred and fifty children were involved and divided into two groups; group I: 75 patients with deciduous tooth decay; and group II:  75 children free from dental caries as a control group. Saliva sample for Streptococcus mutans detection and buccal cells sample for vitamin D receptor gene polymorphism (VDR) assay were taken from each patient. Results: S. mutans count was higher in cases than control group and showed statistically significant difference (p=0.0002). Frequency of GG genotype was higher in control (86.7%) than cases group (64.0%) while GT genotype was higher in cases (36.0%) than control group (13.3%). Risk ratio of GT/GG in cases vs control was significant (p=0.001). Conclusions: GT genotype supports the growth of some bacteria in the oral cavity. S. mutans count was higher in GT genotype, so people with GT genotype are more susceptible to develop dental caries by 3.65-fold and suffer from more DMFT. Susceptibility people should increase care of mouth hygiene.

DOI

10.21608/ejmm.2021.203639

Keywords

Vitamin D gene polymorphism, Streptococcus mutans, decayed, missing and filled teeth index, dental caries

Authors

First Name

Laila

Last Name

Alshibani

MiddleName

A.

Affiliation

B.D.S University of Aljabal AL Gharbi, Libya

Email

-

City

-

Orcid

-

First Name

Ayman

Last Name

Elbaz

MiddleName

-

Affiliation

Professor of Medical Biochemisty Department, Faculty of Medicine, Mansoura University

Email

-

City

-

Orcid

-

First Name

Doaa

Last Name

Masallat

MiddleName

Tawfik

Affiliation

Associate professor of Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University

Email

doaamasallat@yahoo.com

City

Mansoura

Orcid

-

First Name

Rasha

Last Name

Saleh

MiddleName

I.

Affiliation

Lecturer of Dental Public Health and Preventive Dentistry, Faculty of Dentistry, Mansoura University

Email

-

City

-

Orcid

-

First Name

Abeer

Last Name

Abdellatif

MiddleName

M.

Affiliation

Professor of Pediatric Dentistry, Faculty of Dentistry, Mansoura University

Email

-

City

-

Orcid

-

Volume

30

Article Issue

4

Related Issue

27919

Issue Date

2021-10-01

Receive Date

2021-10-31

Publish Date

2021-11-11

Page Start

163

Page End

168

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 30_Issue 4_Pages 163-168.pdf

PDF . 264.7kB

Link

https://ejmm.journals.ekb.eg/article_203639.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=203639

Order

20

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

23 Jan 2023