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188927

Expression Profile of Long Non Coding RNA PVT1 in Patients with Ulcerative Colitis

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Genetics

Abstract

Background: Ulcerative colitis (UC) is a chronic progressive inflammatory bowel disease, many long non coding RNA (lncRNAs) have been studied to have a role in the pathogenesis of Ulcerative colitis. Objective: is to evaluate expression level of long noncoding RNA PVT1 in ulcerative colitis and its association with the severity of the disease. Methodology: Sixty ulcerative colitis patients and 60 subjects were enrolled as controls. LNCRNA PVT1 relative expression level was tested using miScript SYBR Green PCR Kit. Results: Results showed significant differences between the patients with ulcerative colitis and controls as regard the median of the relative expression level of LNC PVT1 (P<0.0001). Also, there were positive significant correlations between the expression level of LNC PVT1 and AST(r=0.398, p=0.002), WBC(r=0.473, p < 0.0001) in UC patients. The ROC curve analysis of LNC PVT1 revealed; LNC PVT1; AUC=0.784, P<0.0001, cut off point 1.06, sensitivity 73.3%, specificity 83.3%. Conclusion: Serum Lnc PVT1 could be used as a potential biomarker for UC diagnosis and prognosis

Keywords

Ulcerative colitis (UC), long non coding RNA, PVT1

Authors

First Name

Shymaa

Last Name

Ayoup

MiddleName

E.

Affiliation

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt

Email

shymaa.egypt@yahoo.com

City

Al Fayoum

Orcid

-

Volume

30

Article Issue

3

Related Issue

26926

Issue Date

2021-07-01

Receive Date

2021-04-16

Publish Date

2021-07-11

Page Start

135

Page End

141

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 30_Issue 3_Pages 135-141.pdf

PDF . 394.6kB

Link

https://ejmm.journals.ekb.eg/article_188927.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=188927

Order

18

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Expression Profile of Long Non Coding RNA PVT1 in Patients with Ulcerative Colitis

Details

Type

Article

Created At

23 Jan 2023