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188075

Cytomegalovirus in Liver Transplant Patients

Article

Last updated: 28 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

virology

Abstract

Background: Graft survival in liver transplant recipients is significantly lower in patients with a history of CMV infection compared to those without. In the absence of any preventive therapy 75% of recipients develop CMV infection post liver transplant. Objectives: This study detected the incidence of cytomegalovirus in liver transplant patients and evaluated post-transplant risk factors for HCMV and its complications. Methodology: A prospective study was conducted from the September 2018 till March 2020. Sixty subjects were involved; 30 patients were admitted for liver transplantation at the Gastroenterology Surgery Center (GISC), Mansoura university, and 30 donors. MELD score was calculated, blood samples were taken, CMV antibodies and CMV DNA were detected. Post transplantation follow up for 6 months and complications were reported. Results: HCMV viremia was detected in 46.6% recipients and in 10% donors by PCR. One recipient was positive for IgM and the rest were IgG positive and all donors were IgG positive. The most common reported complication after liver transplantation was bacterial infections (46.4%). Conclusions: Half of patients developed CMV infection after transplantation. The commonest risk factors for post-transplant CMV infection were seropositive donor or recipient >60 AU/mL, HCV patients, body mass index >25 and DM. Patients with positive HCMV infection had significantly higher MELD score than those reported negative HCMV.

Keywords

Cytomegalovirus, Liver transplantation, Herpesviridae family, solid organ transplantation

Authors

First Name

Doaa

Last Name

Masallat

MiddleName

Tawfik

Affiliation

Associate Professor of Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University

Email

doaamasallat@yahoo.com

City

Mansoura

Orcid

0000-0002-3856-7999

Volume

30

Article Issue

3

Related Issue

26926

Issue Date

2021-07-01

Receive Date

2021-03-23

Publish Date

2021-07-11

Page Start

81

Page End

88

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 30_Issue 3_Pages 81-88.pdf

PDF . 346.3kB

Link

https://ejmm.journals.ekb.eg/article_188075.html

Detail API

https://ejmm.journals.ekb.eg/service?article_code=188075

Order

11

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Cytomegalovirus in Liver Transplant Patients

Details

Type

Article

Created At

23 Jan 2023