Subjects
-Tags
prevention of hospital infections
Abstract
Background: Allergic rhinitis (AR) is an immunoglobulin E (IgE) mediated inflammatory chronic disorder of the nasal mucosa caused by contact to allergens which affects a significant percentage of population. Th17 cells might be involved in the acute phase of the allergic reaction. Th17 cells are regulated by IL-23, which is a member of the IL-12 cytokine family. IL-23 was suggested to be a pivotal cytokine involved in the pathogenesis of AR and may become a novel target in the treatment of AR. Objective: Here we investigate the role of serum IL-23 and its correlation with serum total IgE level in AR. Methodology: This case control study included the investigation of 48subjects. Blood samples were collected for measuring serum IL-23 and total IgE levels by ELISA. Results: positive correlation was found between IL-23 and total IgE serum level in AR patients. Conclusion: Positive correlation was found between serum IL-23 and serum total IgE levels in allergic rhinitis patients.
Keywords
Allergic Rhinitis, serum IL-23, serum total IgE
Authors
Affiliation
Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt
Email
ayaelaidy9@gmail.com
Orcid
-Link
https://ejmm.journals.ekb.eg/article_188069.html
Detail API
https://ejmm.journals.ekb.eg/service?article_code=188069
Type
New and original researches in the field of Microbiology.
Publication Title
Egyptian Journal of Medical Microbiology
Publication Link
https://ejmm.journals.ekb.eg/
MainTitle
Correlation between serum IL-23 and serum total IgE levels in allergic rhinitis patients