Subjects
-Abstract
Background: Helicobacter pylori may be associated with unexplained iron-deficiency anemia (IDA). Hepcidin is an acute-phase reactant but its relation to H. pylori and IDA has not been elucidated. Objective: to investigate serum hepcidin in H. pylori infected patients and its role in IDA. Methodology: This study was performed on 70 patients infected by Helicobacter pylori. They were divided into two groups, group A: 35 H. pylori infected patients without iron deficiency anemia and group B: 35 H. pylori infected patients with iron deficiency anemia. Serum hepcidin was measured by ELISA in both groups while iron, ferritin and total iron binding capacity were estimated in group B. Results: Serum hepcidin was significantly higher in patients with H. pylori infection and iron deficiency anemia. However, non-significant correlation between hepcidin and both iron and ferritin were found. Conclusion: Helicobacter pylori could modulate serum hepcidin level in patients with iron deficiency anemia.
Keywords
hepcidin, iron deficiency anemia, Helicobacter pylori
Authors
MiddleName
-Affiliation
Lecturer of Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Egypt
Email
emadmorad2010@gmail.com
Orcid
-Link
https://ejmm.journals.ekb.eg/article_187002.html
Detail API
https://ejmm.journals.ekb.eg/service?article_code=187002
Type
New and original researches in the field of Microbiology.
Publication Title
Egyptian Journal of Medical Microbiology
Publication Link
https://ejmm.journals.ekb.eg/
MainTitle
Relationship between Hepcidin and Iron Deficiency Anemia in Helicobacter pylori Infected Patients