An increasing incidence of deaths due to tuberculosis (TB) and the known drawbacks of the current existing drugs including the emergence of multi drug-resistant (MDR) and extensive drug resisstance (XDR) TB strains have led to a renewed interest in the discovery of new anti-TB agents. The recent researches focused on natural products have shown a useful way to obtain a potentially rich source of antiinfective drug candidates. For over 50 years, natural products have served us well on combating infectious microorganisms. The microbial and plant secondary metabolites have helped to increase our life span, reduced pain and suffering, and development of new medicine. This review covers the some naturally occurring compounds with anti-TBactivities.