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202336

Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents

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Last updated: 28 Dec 2024

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Abstract

Synthesis and antimicrobial screening of new series of hydrazide-hydrazones were described. Where, regiospacific alkylation of 2-oxonicotinonitriles1a,b with ethyl bromoacetate followed by hydrozinolys is afforded acetic acid hydrazides3a,b. The latter compounds were condensed with a variety of carbonyl containing compounds to give the target compounds of hydrazide- hydrazone derivatives 4a,b, 5a,b and6a-h. While, reaction of 3 a,b with acetyl acetone gave pyrazole derivatives7a,b. The antimicrobial activity of the new synthesized compounds 4b, 5c, 5e and 6bshowed a good activity against tested fungi (Aspergillus niger), while, all the tested compounds have a good and moderate activity against G (+ve) and G (-ve) bacteria.

DOI

10.18576/jpac/040207

Keywords

2-Oxonicotinonitrile, Hydrazide-hydrazone, Antimicrobial

Authors

First Name

H. A.

Last Name

El-Sayed

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Affiliation

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.

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First Name

A. H.

Last Name

Moustafa

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-

Affiliation

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.

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City

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Orcid

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First Name

H. M.

Last Name

Awad

MiddleName

-

Affiliation

Department of Tanning Materials and Leather Technology, National Research Centre, Dokki 12622, Cairo, Egypt.

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First Name

M.

Last Name

Abd El-Moneim

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt.

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Orcid

-

First Name

A.

Last Name

Esmat

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt.

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Volume

4

Article Issue

2

Related Issue

28514

Issue Date

2018-05-01

Receive Date

2021-10-31

Publish Date

2018-05-01

Page Start

53

Page End

59

Online ISSN

2357-0210

Article File

JPAC_Volume 4_Issue 2_Pages 53-59.pdf

PDF . 568.1kB

Link

https://jpac.journals.ekb.eg/article_202336.html

Detail API

https://jpac.journals.ekb.eg/service?article_code=202336

Order

202,336

Type

Original Article

Type Code

2,018

Publication Type

Journal

Publication Title

Journal of Pharmaceutical and Applied Chemistry

Publication Link

https://jpac.journals.ekb.eg/

MainTitle

Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents

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Article

Created At

23 Jan 2023