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200536

Validated HPLC Method for Simultaneous Determination of Aripiprazole and Co-Administered Clonazepam in Spiked Human Plasma

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Last updated: 28 Dec 2024

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Abstract

A sensitive and selective high performance liquid chromatographic method was developed and validated for the simultaneous quantification of Aripiprazole and co-administered Clonazepam in spiked human plasma. Aripiprazole, Clonazepam and the internal standard Citalopram were extracted from plasma and analyzed on a reversed-phase C18 column using a mobile phase consisting of acetonitrile and 0.05M potassium dihydrogen orthophosphate (pH= 3.6) in a ratio of (40: 60, v/v). The ultraviolet (UV) detection was at 220 nm. The method was linear over concentration range (20-1000 ng mL-1) for both drugs. The method is very simple and allows obtaining a very good recovery of the analytes.

DOI

10.18576/jpac/030108

Keywords

aripiprazole, Clonazepam, plasma, HPLC, co-administered

Authors

First Name

Christine

Last Name

M. El-Maraghy

MiddleName

-

Affiliation

Analytical Chemistry department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 11787 6th October city, Egypt.

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Orcid

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First Name

Hesham

Last Name

Salem

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry department, Faculty of Pharmacy, Deraya University, Minia, Egypt.

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City

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Orcid

-

First Name

Sawsan

Last Name

M. Amer

MiddleName

-

Affiliation

Analytical Chemistry department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, 11562Cairo, Egypt.

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City

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Orcid

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First Name

Marianne

Last Name

Nebsen

MiddleName

-

Affiliation

3Analytical Chemistry department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, 11562Cairo, Egypt. 4Pharmaceutical Analytical Chemistry department, Faculty of Pharmacy & Drug Technology, Heliopolis University, 3 Cairo Belbeis desert road, 2834El- Horria, Cairo, Egypt.

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Volume

3

Article Issue

1

Related Issue

28292

Issue Date

2017-01-01

Receive Date

2021-10-20

Publish Date

2017-01-01

Page Start

5

Page End

9

Online ISSN

2357-0210

Article File

JPAC_Volume 3_Issue 1_Pages 5-9.pdf

PDF . 694.8kB

Link

https://jpac.journals.ekb.eg/article_200536.html

Detail API

https://jpac.journals.ekb.eg/service?article_code=200536

Order

200,536

Type

Original Article

Type Code

2,018

Publication Type

Journal

Publication Title

Journal of Pharmaceutical and Applied Chemistry

Publication Link

https://jpac.journals.ekb.eg/

MainTitle

Validated HPLC Method for Simultaneous Determination of Aripiprazole and Co-Administered Clonazepam in Spiked Human Plasma

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Article

Created At

23 Jan 2023