In the recent decades, the use of traditional medicine worldwide has tremendously increased. The gastroprotective effects of aqueous leaves extract of Artemisia herba alba [Asso] were investigated against aspirin-induced gastric lesion in male albino rats. Aspirin [10mg/kg body weight] was orally administered to fasting male albino rats [n=6]. The acute mucosal damage was measured 30 min later. The oral administration of aqueous leaves extract of Artemisia herba alba before aspirin led to gastric protection detected by a decrease in both ulcers number and gastric fluid contents. The gastroprotective effects of Artemisia herba alba aqueous leaf extract at 2.5; 5 and 10 ml/kg body weight, as indicated by number of ulcer, were 16.7%, 56.4% and 74.8%, respectively. In conclusion, a concentration-dependent protective effect of the aqueous leaves extract of Artemisia herba alba against stomach injury induced by aspirin was achieved. This protective effect against ulcer formation may support the traditional use of Artemisia herba alba extract in treatment and protection.