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200515

Design, Synthesis and Hypolipidemic Activity of Novel Hydrazones of Nicotinic acid Hydrazide

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Last updated: 28 Dec 2024

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Abstract

Synthesis of novel N-acyl hydrazones of nicotinic acid hydrazide via condensation of nicotinic acid hydrazide 3 with the corresponding aldehydes 1, 2 are described. Their hypolipidemic activities were evaluated in high cholesterol diet fed rat model. The hydrazones were found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycerides in hyperlipidemic rats to a greater degree than the reference gemfibrozil.

DOI

10.18576/jpac/020304

Keywords

2-Tosyloxybenzaldehyde, 4-Tosyloxybenzaldehyde, fibrates, Cholesterol, Triglycerides and Hypolipidemia

Authors

First Name

Moustafa

Last Name

O. Aboelez

MiddleName

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Affiliation

1Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519-Egypt. 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, 82524-Egypt.

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First Name

Omar M. Elhady

Last Name

M. Elhady

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524-Egypt.

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Orcid

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First Name

Montaser

Last Name

S. A. Shaykoon

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-AzharUniversity, Assiut, 71524-Egypt.

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Orcid

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First Name

Mai

Last Name

E.Shoman

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-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519-Egypt.

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Orcid

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First Name

Sanaa

Last Name

A. Ahmed

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Medicine, Sohag University, Sohag, 82524-Egypt.

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Orcid

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First Name

Gamal El-Din

Last Name

A. Abuo-Rahma

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Medicine, Sohag University, Sohag, 82524-Egypt.

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Volume

2

Article Issue

3

Related Issue

28289

Issue Date

2016-09-01

Receive Date

2021-10-20

Publish Date

2016-09-01

Page Start

39

Page End

43

Online ISSN

2357-0210

Article File

JPAC_Volume 2_Issue 3_Pages 39-43.pdf

PDF . 381.4kB

Link

https://jpac.journals.ekb.eg/article_200515.html

Detail API

https://jpac.journals.ekb.eg/service?article_code=200515

Order

200,515

Type

Original Article

Type Code

2,018

Publication Type

Journal

Publication Title

Journal of Pharmaceutical and Applied Chemistry

Publication Link

https://jpac.journals.ekb.eg/

MainTitle

Design, Synthesis and Hypolipidemic Activity of Novel Hydrazones of Nicotinic acid Hydrazide

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Article

Created At

23 Jan 2023