Hyperchem 7.5 is one of the used and authentic molecular modeling software for constructing molecular structures, computing their optimum geometries etc. It characterizes and predicts the structure and stability of chemical systems. It also calculates dipole moment, charge density, spin density, electrostatic potential, heats of hydration etc. In the present study, optimization of thiazolidine-2,4-diones and their QSAR properties were determined like hydrophobic character of the drug, surface area, volume etc. using AM1 semi empirical calculations. We have determined the log P of thiazolidine-2,4-diones to find their hydrophobicity because more the value of log P, more will be the hydrophobic character means less polarization depends on nature of substituents.