Bisdimedone derivatives were synthesized by the method adopted by Horning and Honing. All the newly synthesized compounds showed antimicrobial activities against certain bacterial and fungal strains. The compounds 2-(2-chloro-phenyl)-5-bis(1,3diketo-5,5-dimethyl cyclohexyl)-methylfuran and 2-(4-flor-phenyl)-5-bis(1,3diketo-5,5-dimethyl cyclohexyl)methylfuran showed good activity against Proteus mirabilis and Klebsiella pneumonia and 2-(4-chloro-phenyl)-5-bis(1,3diketo-5,5-dimethyl cyclohexyl)-methylfuran and 2-(2-chloro-phenyl)-5-bis(1,3diketo-5,5-dimethyl cyclohexyl)-methylfuran showed prominant activity against Staphylococcus aureus. Bisdimedone derivatives shows fungicide activity as well.