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199929

Synthesis of Some New Fused Pyridines and Prediction their Biological Activity via PASS INET.

Article

Last updated: 28 Dec 2024

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Abstract

A new series of fused heterocyclic compounds containing pyridine moieties were prepared via the reaction of 2-amino-6-(methylthio)-4-phenylpyridine-3,5-dicarbonitrile with some halo reagents, active methylenes, acetic anhydride, phenylisothiocyanate, hydrazine hydrate or thioacetamide. Accompanied with Predictions of the activity spectra of some selected compounds using PASS INET.at Pa > 70%, showing high probability of Atherosclerosis treatment, Antineoplastic, DNA intercalator, Protein kinase inhibitor and Signal transduction pathways inhibitor.

DOI

10.12785/jpac/010202

Keywords

phase transfer catalysis, Pyridine, pyrrole, Pyrimidine, pyrrazole, fused pyridine, Pass Inet

Authors

First Name

A. M.

Last Name

El-Sayed

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Sohag 82524, Egypt.

Email

-

City

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Orcid

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First Name

H.

Last Name

Abdel-Ghany

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Sohag 82524, Egypt.

Email

-

City

-

Orcid

-

First Name

A. A.

Last Name

Amer

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Sohag 82524, Egypt.

Email

-

City

-

Orcid

-

First Name

A. M.

Last Name

Ahmed.

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Sohag 82524, Egypt.

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-

City

-

Orcid

-

Volume

1

Article Issue

2

Related Issue

28200

Issue Date

2015-09-01

Receive Date

2021-10-17

Publish Date

2015-09-01

Page Start

28

Page End

34

Online ISSN

2357-0210

Article File

JPAC_Volume 1_Issue 2_Pages 28-34.pdf

PDF . 461.5kB

Link

https://jpac.journals.ekb.eg/article_199929.html

Detail API

https://jpac.journals.ekb.eg/service?article_code=199929

Order

199,929

Type

Original Article

Type Code

2,018

Publication Type

Journal

Publication Title

Journal of Pharmaceutical and Applied Chemistry

Publication Link

https://jpac.journals.ekb.eg/

MainTitle

Synthesis of Some New Fused Pyridines and Prediction their Biological Activity via PASS INET.

Details

Type

Article

Created At

23 Jan 2023