The present study was carried out to evaluate the protective effects of vitamins C, E and DMSA against lead acetateinduced histopathological changes in the livers, kidneys and spleen of albino rats. Exposed rats to Lead acetate (100 ppm) 
exhibited degeneration and necrosis of hepatocytes associated with hemorrhage. The Kidneys showed severe tubular nephrosis 
and necrosis and periglomerular lymphoid cell reaction and dilatation of renal tubule. Hyaline tubular cast associated with 
hemorrhage was also observed. Exhaustion of lymphoid elements in the splenic white and red pulps was noticed. Moreover, 
necrosis of lymphocyte in the white and red pulps associated with hemorrhage had occurred. Co-administration of DMSA with 
lead acetate resulted in reducing the severity of pathological changes induced by lead on the affected organs compared to the lead 
acetate-intoxicated group. There was a significant improvement in lead acetate-induced the hepatic, renal and splenic 
histopathological changes by the administration of vitamins C and E as compared with DMSA treated rats. In contrast, significant 
recovery of the histological picture of liver, kidney and spleen in the lead acetate-induced hepatotoxicity, nephrotoxicity and 
splenic toxicity occurred after treatment with both DMSA and vitamin C combined with vitamin E. These results indicated that 
combination of DMSA, as a chelating agent for lead, with both vitamins C and E, as antioxidants; provide complete protection 
against lead-induced hepatotoxicity, nephrotoxicity and splenic toxicity in male albino rats.