Argel (Solenostemma argel) is a traditional edible herb that is 
commonly used in folkloric medicine for the treatment of rheumatic pain, 
inflammation, hyperlipidaemia, hyperglycaemia and antimicrobial agent
due to its rich in bioactive component which act as antioxidants. 
Forty-eight male albino rats were used in biological experiments. 
Rats were fed the basal diet for two weeks prior to conducting the 
experiment. Initially, rats divided into six main groups and fed on rations 
for 42 days as follows: the negative control group (the first group) was fed 
on the basal diet. Forty male albino rats were fed on a basic diet and 
stimulated with carbon tetra chloride (CCl4( in paraffin oil (50% v/v, 2 
mL/Kg) twice a week by subcutaneous injection to induce chronic liver 
damage, then divided into 5 groups numbered from group 2 to group 6. 
Rats of the positive control group were fed basal diet until the final 
experiment. Group 3 and 4 rats were treated with dry leaves (0.5g and1.0g, 
respectively) of Argel. Also, group 5 and 6 were fed on 50 ppm and 100 
ppm of hydroethanolic extracts orally, respectively. 
Biochemical analyses as serum ALT, AST, ALP and MDA were 
significant decreased in rats fed on dried and extracts in Argel compared 
to positive group. In Contrast, it could be that SOD activity in rat groups 
was significant increased compared to positive group. Also, Argel extracts 
had highest effect for liver parameters than dried Argel.
These results are concluded that Argel could be suggested to the 
hepatoprotective effect of Argel may be due to its antioxidants content and 
free radical scavenging effect.