Throughout the ages and with the changes of nature, humanity stands now at a turning point in its relationship with the planet and its ecosystems. Architecture has been derived from nature as a source of inspiration and biological formation. The idea that biological simulation is a science that observes and studies nature as a concept that changes the awareness of biological simulation. Through the adaptive trend in design, integration with nature and climatic changes conditions, using technologies that are compatible with the surrounding environment. The problem is the gap between the industrial and the simulated biological systems' intellectual approach. The interior design and architecture became not adapted to their environment, but rather separate from the biological systems. The goal is to create an interior architecture with an adaptive system characterized by integration with the natural environment through the concept of "biological simulation" and "adaptive architecture" to reach sustainable designs. That is by linking the scientific method and the descriptive approach through an analytical view of the concept of biological simulation and adaptive design development. Finally, the research can reach the transformation of the intellectual approach into the simulation of the natural adaptive approach in interior design with attention to the cultural role and guidance towards protecting and respecting the environmental systems.