Aim: Access site is one of the initial steps in the endovascular management of chronic lower limb ischemia. In addition to antegrade contralateral and ipsilateral, the retrograde transpopliteal approach is suggested to be used in certain indications. This study aimed to describe the feasibility and complications of this approach. Patients and methods: Retrograde transpopliteal approach was used in 23 patients, attending Suez Canal University Hospital for the treatment of chronic lower limb ischemia, in whom the antegrade approach was not possible. The success to access the popliteal artery, crossing the lesion, effectively dilating the artery, patency up to one month and complications rate were measured. Results: In all patients the popliteal artery was successfully accessed and the lesion was crossed. Post dilatation contrast study confirmed successful dilatation, that was maintained up to one month follow up. No complications were recorded. Conclusion: Retrograde transpopliteal approach is a feasible and safe alternative method to approach SFA and CFA lesions when the antegrade approach cannot be used.