Background: Numerous oncoplastic procedures are now available for treatment of breast cancer. Oncoplastic procedures had expanded the spectrum of breast conservative surgery. It is difficult to plan for resection of medial breast tumors as the scars are apparent and deformity is so eminent. The aim of the work is to assess the latero- central glandular pedicle technique as an oncoplastic procedure for treatment of medial quadrant breast cancer as regard oncological safety, surgical outcomes and patient satisfaction.  Patients and method: This study included 15 female patients with a mean age of 43 years (20-60 years) and with invasive breast cancer at upper and lower medial quadrants. They were treated by wide in excision with safety margin followed by reconstruction of defects using latero-central glandular pedicle technique. The patients were followed for 6 months for postoperative complications and cosmetic outcome.  Result: In our study the mean age of the 15 patients was 43 years (20-60 years). 60% of the breast tumors were in the upper inner quadrant and 40% of them were in the lower inner quadrant. The largest tumor size was 3.2 cms, the smallest one was 1cm and the mean tumor size was 2 cms±0.47. The mean breast cup size for the whole study was 4.33±1.56 which stand for D. Our mean operation time was 107±14.50 minutes (1 hour and 45 minutes). The longest post-operative stay period was 3 days. The postoperative complications occurred three cases (20%) in the form of: 2 cases(13%) of wound infection and 1case (7%) of stitch sinus . none of the patients had recurrence during postoperative follow up period of six months duration.as regard the cosmetic outcome which was estimated via a score system graded from one to five, The overall mean score of our study was 4.23±0.86 which falls between very good and excellent.  Conclusion: The latero-central glandular pedicle technique is an oncoplastic procedure for treatment of medial quadrant breast cancer with main advantages of low rate of postoperative complications and better cosmetic outcome.