Background: Laparoscopic sleeve gastrectomy had gained popularity and acceptance among bariatric surgeons, mainly as a result of its low morbidity and mortality. Single-incision laparoscopic surgery (SILS), the most recent development in minimally invasive surgery, allows operations to be carried out through, only a single incision. The aim of our study was to evaluate the efficacy and safety of a laparoscopic single-incision sleeve gastrectomy for morbid obesity in comparison with multiport laparoscopic sleeve gastrectomy.   Patients and methods: This is a prospective comparative study conducted between June 2012 to November 2015, which included 35 morbidly obese patients, divided into 2 groups. Group (A) included 18 patients who underwent multiport laparoscopic sleeve gastrectomy and group (B) included 17 patients who underwent single-incision laparoscopic sleeve gastrectomy.   Conclusion: Laparoscopic single-incision sleeve gastrectomy seems to be safe and effective as same as conventional multiport sleeve gastrectomy. However, additional work must be carried out before these techniques achieve the level of standardization.