The expansion of total skin-sparing mastectomy (SSM) criteria over time has allowed greater numbers of patients to experience the aesthetic and psychological benefits that SSM and nipple-sparing mastectomy (NSM) approach provided. However, we have to weigh the oncologic safety, and the postoperative compli- cation. Superolateral radial incision provides an exploratory incision with minimal complication.   Patients and methods: This study was a prospective study conducted on 28 female patients with invasive breast cancer requiring mastectomy who underwent skin-sparing mastectomy and nipple sparing mastectomy via the superolateral radial incision.   Conclusion: Skin-sparing mastectomy and nipple-sparing mastectomy via superolateral radial incision is an oncologically safe procedure with a low-postoperative complication rate and an excellent esthetic outcome.