Objective: The purpose of this study is to compare the operative and postoperative outcomes of laparoscopic adrenalectomy (LA) with open adrenalectomy (OA) for benign adrenal lesions less than 6 cm in size. Patients and methods: From March 2011, to January 2015, patients with adrenal tumours were allocated to either unilateral laparoscopic or open adrenalectomy. Patients with adrenal masses >6 cm, suspected adrenal malignancies, and adrenal metastasis were excluded. Demographic data, operative findings, operative complications, postoperative complications, and duration of hospital stay were recorded and compared in both groups. Results: Two groups of patients (18 in each group) were allocated in this study. Both groups were statistically similar regarding age, gender, body mass index (BMI), and American Society of Anesthesiologists (ASA) score. Two patients in the laparoscopic group were converted to open resection. The mean operative time in the laparoscopic group was significantly higher. However, the mean operative blood loss, need for analgesics, time of passing flatus after surgery, the duration of hospital stay were significantly lower in the laparoscopic group. Postoperative complications, hemodynamic stability and need for blood transfusion showed no statistical difference in both groups. Conclusions: Laparoscopic adrenalectomy is a safe operative procedure offering faster recovery, and shorter hospital stay. Hence, we recommend laparoscopic adrenalectomy as the first line treatment for benign adrenal masses less than 6 cm in size.