Background: Metastatic nodules are the most common malignancy affecting the liver. Colo- rectal cancer is the most common primary tumor sending metastases to liver, less commonly neuro-endocrine tumors and others. Aim: To study the effect of staged resection (resecting the malignant primary site, neo- adjuvant chemotherapy for 1-3months, liver metastasectomy then chemotherapy completion). Patients and methods: Eighteen patients were admitted to Zagazig University hospitals with hepatic metastases from different primary sites (mostly colorectal cancer) from June 2012 to September 2015. All patients were assessed clinically and radiologically. Neo-adjuvant chemotherapy was given to synchronous colorectal liver metastases. Results: This study included 10 (55.5%) females and 8 (44.5%) males with mean age 43 years old. Thirteen patients had hepatic metastases from colorectal cancer. Classical approach was done in 16 patients. 14 patients had anatomical resection while the remaining 4 patients had non-anatomical resection. Postoperative complications occurred in nine patients while recurrence was only in 4 patients (two of them died during the follow-up period). Conclusion: Liver resection for liver metastases from different primary sites improved the 5 years survival when used combination with neo-adjuvant chemotherapy