The purpose ofthis study is to investigate the incidence and predisposingfactors oflower limb deep venous thrombosis (DVT) in cirrhotic patients, and to evaluate the use of anticoagulation therapy (AT) with low molecular weight heparin (LMWH) and warfarin for managementofDVT in these patients. The study was conducted on 622 cirrhotic patients from whom the incidence of lower limb DVT was obtained. Six cirrhotic patients with lower limb DVT and twenty four cirrhotic controls were fully investigated  and compared. The patients and controls were age, sex and Child-Pugh  score matched. All the patients were assessed  according  to a protocol including prothrombin time, prothrombin concentration, international  normalized ratio (INR), protein C, proteinS, antithrombin III, serum bilirubin, serum albumin, platelet counts, HBs-Ag and HCV antibody. Results revealed that the prevalence of DVT in our cirrhotic patients was 0.96%. The use of AT in cirrhotic patients needs meticulous follow up for early management of any complications and the screening for esophageal varices with prophylactic band ligation if risk signs were present is of great importance