Objectives: After conservative management  of breast cancer, two third are at risk of local relapse, a risk which is largely reduced by radiotherapy. Seroma formation after mastectomy typically delays recovery and adds to morbidity. Aim  of  the  work:  This  study aims  at  collection  of  the  seroma  fluid  after  conservative breast surgery and detection of malignant cells in the drained fluid and its relation with local recurrence. Methods: Twenty three patients with early breast cancer were included  in the  study and after conservative breast surgery. Seroma fluids were collected from the drain for detection of malignant cells then these patients were followed for twelve to twenty four months for detection oflocalrecurrence Results:  There was a high significance in local recurrence associated  with cases showing malignant second samples compared with those with negative one (X2=29.076, p=O.OOO). Conclusions: Persistent  presence of malignant  cells in the postoperative  drained fluid in females with early breast cancer is predictive for local recurrence. However long terms follow up and an increase in the number of the studied cases is recommended to confirm these results.