Introduction: A leak from an intestinal anastomosis is the complication  most feared by the colorectal surgeon. The role of omentoplasty in securing colorectal anastomoses  shows some controversy:  being recommended  by some authors,  being  of equivocal  value to others  and to be recommend against by a third group of authors. Collagen-bound  fibrin sealant sheets have recently been used in many aspects of surgery; for example: Hernia, GI, ophthalmic, gynecologic & obstetric, renal, vascular and cardiac surgeries; and many experimental animal studies proved its efficacy in  securing  GJ anastomoses.  The  safety  and  feasibility  of using collagen-bound fibrin sealant has been proven. Its application for sealing colonic anastomosis is a new field of its application and needs to be evaluated. Aim: To evaluate and compare the efficacy of both omentoplasty and a newly introducedfibrin sealant; TachoSil®; in decreasing the rate of anastomotic leakage in colorectal anastomoses. Results:  97 patients were included; 48 in omentoplasty group and 49 in TachoSil® group. The rate of clinical leakage in omentoplasty group was 8.3% and in TachoSil® group was 2%. Three out of four leakages in the omentoplasty group were sever(>500 cc/day) and the only case in TachoSil® group was less sever (<500 cc/day). The average hospital stay in omentoplasty group was 9.3 days and in TachoSil® group was 7.2 days (P<0.05). Conclusion: Omentoplasty proved no beneficial effect in sealing colonic anastomoses. There is a trend proving that TachoSil® is more effective than omentoplasty in preventing anastomotic leakage. The use of the collagen-bound fibrin sealant TachoSil® appears to be beneficial, being better than omentoplasty  regarding the length of hospital stay and the severity of leakage, if leakage is inevitable.