Background: In recent years laparoscopic  splenectomy (LS) has gained acceptance  as a viable alternative to open splenectomy. Laparoscopic splenectomy is evolving and may become the standard operative method for the treatment of the problem spleen. Patients and methods: From July 2012 till December 2013, 20 patients with clinical immune thrombocytopenic purpura (ITP) were referred as surgical candidates. Two ofthem (10%) were converted to open, and the other 18 underwent successful LS. The operative approach was performed with the patient in the right lateral decubitus position, with extensive use of the ultrasonic dissecting shears. Results:  There were 20 patients in the study, twelve women and eight men with a mean age of28 years (18-38). Immune thrombocytopenic  purpura (ITP) was the indication for surgery. Laparoscopic splenectomy was intended in all patients and successfully completed in 18 patients (90%). Two cases (10%) required conversion to open splenectomy, due to intraoperative hemorrhage  which could not be controlled laparoscopically.   Length  of hospital stay (LOS) was 2.3 ± 0.8 days. The two major complications (10%) were intraoperative hemorrhage which required conversion to open splenectomy The two minor complications were trocar site infection and hernia. The average operative times (150 ± 48 min) improved as the study progressed. This improvement was believed to be due to the learning curve. Conclusion: Laparoscopic  splenectomy (LS)  may be considered  the standard of care for patients who require splenectomy  for ITP  Laparoscopic  splenectomy  results in less  patient disability, shorter hospitalization, and probably less perioperative morbidity