Background:     Laparoscopic     cholecystectomy     has     become    the   gold     standard     for cholecystectomy.  Single-incision  laparoscopic  operations  have  recently  emerged  as  a less invasive alternative to conventionallaparoscopy as the tendency of minimizing surgical trauma encourages the use of new approaches in laparoscopic surgery which has the potential of further reducing the trauma  of surgical access. This  may  lead to reduced  post operative  pain and improved patient cosmesis.  Single-incision  laparoscopic  surgery (SILS) is a rapidly evolving field as a bridge between  traditional  laparoscopic  surgery and natural  orifice transluminal endoscopic surgery (NOTES). The aim of this work was to evaluate the role of SILC  for the management of chronic calculous cholecystitis as regards its feasibility and outcome. Patients   and  methods:  Between  January  2010  and  January  2014,  120  patients  were subjected to SILC. A single 2.5cm long semicircular supraumbilical skin incision was used. Pneumoperitoneum was  established  with the Veress access  needle.  Abdominal  cavity  was entered through three trocars: 10-mm trocar for camera and two 5-mm trocars, each placed 1-2cm laterally and cranially from the 10-mm trocar, with carefully placed sutures to puppeteer the gall bladder and thus aid retraction. Results: In this series, out of 120 patients, 90 patients (75%) were females, and the remaining 30 patients (25%) were males, with an average age of 32.8 years (range, 23-60 years), and 36 female patients had undergone previous lower abdominal  surgery (Cesarean  section or other gynecological procedures). Mean operative time was 58.6 min (range 40-120 min). Out of 120 patients, 106 patients (88.3%) successfully underwent SILC. In 10 patients (8.3%) an additional epigastric port was used, in 3 patients (2.5%) conversion to the traditional4-port laparoscopic technique was done, and conversion to open surgery was done in one patient. Conclusions:  SILC  using   conventional   laparoscopic   instrumentation   is  an  effective alternative to standard four-incision  laparoscopic  cholecystectomy  in selected patients,  it is safe, feasible, and reproducible. The operating times are reasonable and can be lessened with experience.