Introduction:  Appendicitis  is  the  most  common  surgical  emergency  in  the  pediatric population.  Despite  the  widespread  prevalence   of  the  disease,    there  is  little  consensus regarding the diagnosis and management  of appendicitis.  The aim of the study is to compare the surgical outcome  of laparoscopic  appendectomy  in  children  for perforated  appendicitis using perioperative triple versus a single antibiotic based regimen. Patients  and  methods:   A retrospective review  was done  for all the  children  who had  a laparoscopic appendectomy  for perforated appendicitis in a tertiary pediatric surgery center in UAE in the period  from June 2009 to January 2014. A total of 56 children was included in the study  Group A, monotherapygroup 'MG' (31 cases) who were managed with  piperacillinl tazobactam  and  group  B,  triple  therapy  group   'TG'  (25  cases)  who  were managed  with Amoxicillin Clavulanate, Metronidazole and amikacin. Results:  There were 52% males and 48%  females, mean age were 8.3 ± 1.5 years.  There were 26% cases versus 28% cases in MG and TG respectively  who required more than 7 days antibiotics. Mean  total length of hospital  stay was  statistically  significant more in TG than MG. There was significant difference between both groups (13% versus 36% in MG and TG respectively)  for the need to replace the IV cannula before 72 hours. Conclusion: Monotherapy antibiotic management  of perforated appendix in  children was equally effective as triple antibiotic therapy in the current study population  for the infectious morbidities. Monotherapy antibiotic management  showed significant less incidence of intravenous  cannula morbidities and shorter total hospital stay