Aim: Is to compare the short-term outcome of hepatic resection and radiofrequency ablation (RFA) in two groups of patients with a solitary hepatocellular carcinoma (HCC) less than 5 em in Childs A cirrhotic patients.
Patients and methods: The study comprised 60 patients; 52 (86.7%) males and 8 (13.3%)
females, with mean age 45.2±9.6, range 26-67 years. The patients were randomized into
2 groups: Resection group (n=28 patients) assigned to undergo hepatic resection and radiofrequency group (n= 32 patients) assigned to undergo RFA. The morbidity; hospital stay; overall survival; disease-free survival; psychological and physical welfare of the patients were assessed during the follow up period.
Results: There was non-significant difference (P >0.05) in both groups as regards the
morbidity (21.4% in resection group versus 15.6% in RFA group).The mean hospital stay was
7±2.9 in resection group and 1±1.2 in RFA group; with a significant shorter stay (P<0.001) in RFA group. Patients included in RFA group showed significantly increased scores of psychological and physical welfare compared to resection group (P<0.001). Subgroup analysis showed non significant difference between both groups as regards the 2 years overall survival
& recurrence-free survival in tumours less than 3cm.On the other hand, surgical resection
was superior to RFA for 2 years overall survival & the recurrence-free survival in subgroup analyses for lesions > 3cm, <5cm.
Conclusion: In patients with ChildA cirrhosis with solitaryHCC >3cm, RFAprovided results with non-significant difference to surgical resection with the advantages of being less invasive, shorter hospital stay, and better quality of life. While in tumours between 3 and 5 em, surgical resection was superior to RFA having better overall survival and tumour-free recurrence