Introduction: Lipoinjection can be used to give extra-volume during breast enhancement surgeries and to co"ect various types of depressed deformities of the breast, but certain problems remain as unpredictability and low graft survival which are a major concern in plastic surgery. Different trials and techniques were done for enhancement of the take and vascularity of the fat grafting. Platelet Rich plasma plays an important role in the process of vascularization of the  grafted  fat  due  to  its  high  content  of  Platelet Derived  Growth  Factor(PDGF). Methods: 20 patients who were candidates for breast augmentation were included in the study and were divided into two groups; one had fat injection with PRP in the breast and the other had breast lipoinjection with Colemantechnique. A questionnaire follow up was designed on Likert scale on grades 0-4 evaluating the volume and fat survival with statistical analysis. Results: Group B (with PRP) showed overall better results. All patients with PRP showed moderate to good projection post-operatively. 50% of Group B showed no further requirement of secondary procedure. Whereas group A showed moderate to large requirement for secondary augmentation. Conclusion: The increase in the level of PRP and in turn PDGF during the first days after lipoinjection will enhance the graft vascularity and overall survival, thus there is a need to further studies for standardizing the level of PDGF needed to have better take & results with lipoinjection.