Introduction: This study was designed to determine the safety and efficacy of using percutaneous ultrasound-guided radiofrequency ablation  of early breast  carcinoma  in Egyptian  females. Patients: Thirteen patients were included in the study to be treated just before scheduled mastectomy or breast conserving surgery. Method: All patients were contraindicated  or refused to do breast conservative surgery. A needle-shaped treatment electrode, with umbrella spreading end, was placed into the center of the lesions using ultrasound  guidance. A temperature of 85°C was maintained for 10 min. All resected specimens were processed & examined histopathologically using conventional methods searching for viable tumor cells. Results:  In 11 patients (84.6%), a complete ablation of the tumor was achieved. No extensive para-tumoural necrosis was detected in any case. Conclusion: Ultrasound-guided radiofrequency ablation of breast carcinoma is feasible and safe. The success rate depends  on accurate  preoperative diagnostic  imaging as well as the exact position of the needle electrode.