Purpose: To evaluate the role of the serological markers; hs-CRP and fibrinogen, in the prediction of vascular events in peripheral arterial diseases, and if it can be considered as prognostic risk factors for the severity of the atherosclerosis. Methods: From February 2010 through March 2011, 200 subjects were included in this study; they consisted of 140 patients suffering peripheral arterial disease and 60 volunteers as controls. All patients were subjected to full history taking, measuring ABL duplex ultrasound and   blood  sampling  to   measure  plasma  levels  of   hs-CRP  and   fibrinogen. Results: Mean age was (65.69±7.02) and 71.4% were males. hs-CRP and fibrinogen were found highly significant risk factors for peripheral arterial disease prediction, and were also found inversely associated with ABL which means, they can be used as markers for disease progression or severity. Conclusion: hs-CRPand.fibrinogen are associated with increased risk of developing peripheral arterial disease and are considered as predictors of disease severity.