Aim: This prospective randomized trial compares the results of pancreaticoduodenectomy with duct to mucosa pancreaticojejunostomy with external stent versus pancreatico-duodenectomy with invaginating (dunking) end to side pancreaticojejunostomy Methods: This study included 40 patients who underwent surgical therapy for cancer head of  pancreas, between Sep.  2009  and  March 2011  at  Ain  Shams University Hospitals. Patients were randomly assigned to surgical procedures. Patients in group 1 (n 20) underwent pancreaticoduodenectomy with end to side duct to mucosa pancreatico-jejunostomy and external stent, and patients in group 2 (n 20) underwent pancreatico-duodenectomy with invaginating (dunking) end to side pancreaticojejunostomy. Results: In group 1 two patients (10%) developed pancreatic fistula compared to five patients (25%) in group 2.As regards development of intra-abdominal abscess, one patient in group 1 developed  that complication  while two patients (10%) in group 2 developed intra-abdominal abscess. One patient (5%) in group 2 had postoperative bleeding.One patient in group 1 (5%) developed  septicemia  compared to three patients  (15%) in group 2. Two patients in group 2 needed reoperation. Conclusion: Duct to mucosa pancreaticojejunostomy has less post-operative  morbidity as pancreatic fistula, intra-abdominal abscess  and  septcemia than  invaginating (dunking) pancreaticojejunostomy.