Aim: The aim of this work was to assess the safety of liver resection in bilharzial patients with   special   attention   to   the   ability   of   the   bilharzial   liver   to   regenerate. Methods: The study included patients with liver mass indicated for resection. Patients with pathologically proved pure bilharzeal hepatic fibrosis and who fit in Child-Pugh class A or B were selected. Patients underwent liver resection. They were followed up for one year. They were examined serially for their liver functions and liver volumetry. Results: Forty eight patients had liver resection. Of them, 16 had pure bilharzeal fibrosis. The mean age was 59±14 years. There were eight right hepatectomies, three left lateral segementectomies, two left hepatectomies, two non-anatomical resections (for cancer gall bladder) and one IVth segmentectomy. Mean operating time was 155±73 minutes. Mean blood loss was 430±720.72 mls. There were neither operative complications nor mortalities. Mean hepatic volumetry was 854.66±92.32, 1003.68±123.68, 1166.54±65.32 and 1246.12±30.87mls at one, 12, 24 and 52 weeks postoperative respectively. Conclusions:  Resection in bilharzeal liver does not carry added operative risk. Bilharzeal liver has a considerably better regenerating power as compared to cirrhotic liver. It might therefore tolerate resection safely.