Study presented here was conducted to find out the possible positive effect and adding benefits for chicken ration supplement with Nigella Sativa (NS) and curcumin in reducing the aflatoxicosis negative effect on some physiological body parameters, antioxidant status. Two hundreds broiler chicks (Arbor Acres) were arbitrarily divided into 4 groups (5 replicates for each). During the experimental period (45 days), first group (negative control) received basal diet. Other experimental groups (second to fourth) during the first 25th days received basal diet containing 20ppm of aflatoxin (AFB1) then after (26th to 45th days) second group continue in AFB1 free basal diet, while group 3 received (AFB1) free plus Nigella Sativa (black seeds) at dose of 2% of basal diet, while the 4th group was fed a AFB1 free plus (Curcuma longa) turmeric rhizome at a dose 1% of the basic ration. Results disclosed that AFB1 caused decreased body weight, increased morality, edematous carcasses, bleeding, liver surface appeared pale yellowish with reddish strikes, enlarged swollen kidneys, thymus and bursa atrophy with necrosis. Addition of Curcumin and Nigella sativa to broiler chicks' basal diets can ameliorate aflatoxins hazard effect and improve general health, growth rate, liver and kidney's function. Notably NS results were more promising