Monosodium glutamate (MSG) and sulfite are frequently used as flavor enhancer and most applied as food additives in modern nutrition globally. This study planned to investigate the potential toxic effect of MSG on liver and kidney when administered to broiler chickens during the growth period. Forty, day-old, unsexed Ross broiler chicks, they assigned into 4 groups: 10 chicks each, fed on standard diet mixed with 0.75g of MSG/kg (group A), sodium metabisulfite 3.5/kg (group B), 0.75 g MSG + 3.5g sulfite /kg (group C) and control group (group D). Oxidative stress indicators assay such as malondialdehyde (MDA), and superoxide dismutase (SOD), activities were determined. Liver and kidney function testes foe alp enzyme and creatinine metabolite were examined. Histo- architecture of liver and kidney tissues were conducted in all exposed groups. The results indicated that the increase in the determination levels of serum ALP, creatinine, MDA and SOD in all exposed groups in comparison with control. Disturbance in hepatic architecture with hydropic changes in hepatic cells with congestion of the interstitial blood vessels and necrobiosis of renal tubular epithelium.