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Pharmacodynamics evaluation of Eggplant wastes formulated as lyophilized tablets in an attempt for preparation of a bioactive natural antidiabetic dosage form

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Last updated: 28 Dec 2024

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Abstract

Introduction: Eggplant fruits (Solanum melongena L.) are widely consumed worldwide due to their generous composition of nutraceuticals. They are enriched with different classes of phenolic phytochemicals. Among the polyphenolic constituents, the fruit peels show high content of quercetin-3-rutinoside, chlorogenic acid and delphinidine-3-rutinoside. The plant possesses various biological activities such as antioxidant and antidiabetic activities. It can manage type 2 diabetes by controlling glucose absorption. Aim of study: The objective of the present study was to standardize delphinidine-3-rutinoside, chlorogenic acid, and quercetin-3-rutinoside, present in the eggplant peels extract, then formulate the extract as a lyophilized tablet, in order to evaluate its effect on glucose levels in an attempt for preparation of a bioactive natural antidiabetic dosage form. Materials and Methods: Various extracts of Eggplant peels were prepared using different extraction solvents. Pharmacodynamics studies were carried out on formulated lyophilized tablets containing the most promising extract.  Pharmacodynamics study was conducted to assess the effect of the fruit peels extract on the management of blood glucose level in diabetic rats. Results: The results revealed that the Eggplant fruit peels extract in the form of lyophilized tablets could be promising in controlling the high blood glucose level in type 2 diabetic patients, as the freeze-dried tablets of the Eggplant peels extract resulted in lowering the blood glucose level to ~148 mg/dl after 10 days of twice daily administrations to diabetic rats. Conclusion:this report, addresses the important approach of finding and exploiting the significance of using food wastes in drug discovery.

DOI

10.21608/jfcr.2022.245600

Keywords

eggplant peels, anthocyanins - pharmacodynamics- antidiabetic

Authors

First Name

Hana

Last Name

EL Bazzar

MiddleName

-

Affiliation

Senior Students, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt.

Email

hana1807814@miuegypt.edu.eg

City

Cairo, Egypt.

Orcid

-

First Name

Sohayla

Last Name

Mohamed

MiddleName

-

Affiliation

Senior Student, Faculty of Pharmacy, Misr International University, Cairo, Egypt.

Email

sohayla1700704@miuegypt.edu.eg

City

-

Orcid

-

First Name

Yomna

Last Name

Mahmoud

MiddleName

-

Affiliation

Senior Student, Faculty of Pharmacy, Misr International University, Cairo, Egypt.

Email

youmna1701682@miuegypt.edu.eg

City

Cairo, Egypt.

Orcid

-

First Name

Lamia

Last Name

Bazan

MiddleName

-

Affiliation

Pharmaceutical Technology Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt. Misr International University, Cairo, Egypt.

Email

lamyaa.bazan@miuegypt.edu.eg

City

Cairo, Egypt.

Orcid

-

First Name

Noha

Last Name

Ibrahim

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.

Email

nohaibrahim2010@gmail.com

City

Cairo, Egypt

Orcid

-

First Name

Rasha

Last Name

Mahmoud

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.

Email

rasha_ahmed@miuegypt.edu.eg

City

Cairo Egypt.

Orcid

-

First Name

Rania

Last Name

Abou El Ezz

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Misr International University, (MIU), Cairo Egypt.

Email

rania.farouk@miuegypt.edu.eg

City

Cairo Egypt.

Orcid

-

First Name

Hany

Last Name

Ibrahim

MiddleName

Mahmoud

Affiliation

Pharmaceutical Technology Department, Faculty of Pharmacy, Misr International University (MIU),Cairo, Egypt

Email

hani.mahmoud@miuegypt.edu.eg

City

Maadi

Orcid

0000-0002-7863-2492

First Name

Manal

Last Name

Afifi

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Misr International University, (MIU), Cairo Egypt.

Email

manal.shafik@miuegypt.edu.eg

City

Cairo Egypt.

Orcid

-

Volume

2

Article Issue

1

Related Issue

35188

Issue Date

2022-06-01

Receive Date

2022-06-22

Publish Date

2022-06-01

Page Start

74

Page End

83

Online ISSN

2786-023X

Article File

JFCR_Volume 2_Issue 1_Pages 74-83.pdf

PDF . 401.4kB

Link

https://jfcr.journals.ekb.eg/article_245600.html

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https://jfcr.journals.ekb.eg/service?article_code=245600

Order

6

Type

Original research articles

Type Code

1,936

Publication Type

Journal

Publication Title

Journal of Fundamental and Clinical Research

Publication Link

https://jfcr.journals.ekb.eg/

MainTitle

Pharmacodynamics evaluation of Eggplant wastes formulated as lyophilized tablets in an attempt for preparation of a bioactive natural antidiabetic dosage form

Details

Type

Article

Created At

23 Jan 2023