Background:Laminate veneer restorations need minimal preparation and are highly esthetic and biocompatible. However, debonding of laminate veneers without destruction or touching underlying tooth structure is challenging. Laser has afforded a great tool of help. Aim of the Study: to evaluate the effect of Er,Cr:YSGG laser of different power settings on tooth structure chemistry and topography after debonding of laminate veneers. Materials and Methods: Fifteen laminate veneers were prepared and bonded to maxillary central incisors and divided into three groups (n=5) according to laser power settings. Each group was subjected to its respective laser power to debond laminate veneers. Tooth structure chemistry was measured using electron dispersive analytical x-ray, surface roughness was measured by profilometer, SEM used for measuring surface microstructure and time was recorded. Digital microscope used to detect mode of failure. Results: All laminate veneers were debonded with different laser power settings. Calcium and phosphorus showed statistically significant decrease from before bonding to after debonding. Surface roughness showed statistically significant increase from before etching to after etching, but no statistically significant difference after etching and after debonding. Time decreased when increasing power setting. Roughness of fitting surface of laminate veneers showed no statistically significant change before bonding to after debonding. Mode of failure mainly was cohesive with different power settings showing no statistically significant difference. Conclusion: Laser is useful in laminate veneer debonding. It benefits that tooth structure not affected and laminate veneer remained intact with less time and easier technique for debonding.