Background: Maintenance hemodialysis is a treatment to filter wastes as urea and creatinine as well as excess water from the blood in chronic renal failure.Aim: Evaluate the effect of the implementation of nutritional educational module on biochemical and physiological parameters for patients on maintenance hemodialysis. Design: A quasi experimental research design was utilized. Setting:This study was conducted at the dialysis center of Damanhour medical national institute. Subjects: A convenience sample of sixty adult patients aged from 18 to 60 years on maintenance hemodialysis. Tools: Tool I: Socio demographic and clinical data of patients on maintenance hemodialysis structured interview schedule. Tool II: Patients' knowledge regarding hemodialysis treatment and diet. Tool III: Nutritional assessment check list. Tool IV: Biochemical and physiological data. Results:There was statistically significance difference post application of the nutritional educational module regarding biochemical indicators as "Hemoglobin, RBCs, WBCs, HCT, urea, creatinine, sodium, potassium, uric acid, albumin, serum protein, calcium, phosphorus, c-reactive protein, and cholesterol.Also statistically significant relation between the study patient's socio demographic, clinical data, biochemical, nd physiological parameters, and positive correlation was found between physiological data with patient age (P=0.017*). Conclusion: The nutritional educational module illustrate a positive result regarding over all nutritional assessment, a positive outcome as evidence by biochemical parameters as complete blood count, urea, serum creatinine, sodium, potassium, uric acid, serum albumin, liver derived proteins, serum calcium, phosphorus,c-reactive protein, total cholesterol and transferrin, and also positive result regarding physiological parameters as weight, BMI and blood pressure. Recommendation: Replication of the study on non propability sampling.