Post inter hospital cardiac arrest survival rate range from 17 - 32%. Early Warning Signs developed for the inpatient cases, Scoring system generated using the bedside assessment of physiologic parameters to detect of unwell patients and decreases in cardiac arrest rates. The aim of this study was to evaluate the Effect of Educational Program on Nurse's Performance Regarding Rapid Response Code to Prevent Cardiopulmonary Arrest. A quasi experimental design was used to conduct this study. The study was conducted in inpatient unit at Elaraby hospital, Egypt. Convince sample of all Inpatient nurses. Method; Study lasted from the beginning of February 2020 to beginning of December 2020. Tools: three tools for data collection. Self-administered questionnaire for nurses consisted of demographic characteristics and nurse's knowledge, observation checklist, and nurse's attitude. Results; the study finding revealed that, nurse's satisfactory knowledge pre educational program was Zero percentage, post educational program improved to 66%. Nurse's satisfactory practice pre educational program was 16%, post educational program improved to 60%. Also, the nurse's Positive attitude pre educational program was P 16%, post educational program improved to P 56%. Finally, the inpatient arrested cases in last month/critical cases number significant reduced; pre educational program P 7.6%, post educational program P 0%. Conclusion, Application of rapid response code for inpatient unit showed an improvement of inpatient cardiopulmonary arrest that clearly reduced. The study recommended that; increase awareness of Nurses regarding rapid response code to empower and motivate them to adhere to rapid response code guidance for prevent cardiopulmonary arrest.