Background: Sexual harassment is a global, pervasive, social phenomenon that is widespread. That has become a universal in our local community spreading to all standards and divisions in the society. Aim: The study aims to assess the female students' knowledge and self-esteem regarding sexual harassment at Beni-Suef University. Study Design: Descriptive design was utilized in this study. Setting: This study conducted in two theoretical faculties in Beni-Suef University. Sample: : Multistage random sample technique to choment, female students point of views regarding reasons for exposure to harassment in the community, suggested corrective measures to reduce sexual harassment, students' knowledge regarding sexual harassment. (2) Rosenberg's global self-esteem scale. Results: All female students exposed to abuse or harassment previously always exposed to verbal reversals and closer look.42.1% of female students had unsatisfactory total knowledge regarding sexual harassment. Related to self esteem,only about 23.3 % of female students had high level of self-esteem. Conclusion: All the female students previously exposed to harassment. More than two fivth of female students had un satisfactory knowledge about sexual harassment. Less than one quarter of female students had high level of self-esteem. Recommendations: Implement health education program about sexual harassment and improving self esteem.