Traumatic brain injury (TBI) constitutes a major health and socioeconomic problem throughout the world. Traumatic brain injury is a common cause of disability worldwide. Aim of this study was to determine the effect of nursing intervention protocol on controlling extremities muscle contracture for critically brain injured patients. Design: A quasi-experimental research design was utilized in this study. Subjects: A purposive sample of 60 adult patients from both genders admitted to hospital with traumatic brain injury was involved in this study. Setting: data were collected from the Surgical Intensive Care Units at the Surgical Hospital affiliated to Ain Shams University. Tools: three tools were used for data collection (I) A structured interview questionnaire sheet, which included (a) Socio Demographic Assessment Sheet, (b) Clinical Data Assessment Sheet, (c) Glasgow Coma Scale Assessment Sheet. (II) Muscle Contracture Assessment Sheet, which included (a) End feel of the affected extremity Assessment Sheet, (b) Observational Checklist of upper and lower extremities, and (III) Goniometer Scale Assessment sheet. The results: the study revealed that, there was a highly statistically significant difference between the study and the control group regarding the level of muscle contracture. Conclusion: Range of motion exercises, splinting of ankle and wrist, and changing position every 2 hours applied to traumatic brain injured patients have a positive effect on reducing and controlling extremities muscle contracture. Recommendation: Range of motion exercises should be taken into consideration as a routine nursing care for each patient with traumatic head injury.