Two field experiments were соnduсtеd аt the Experimental Farm, Faculty of Agriculture, Fayoum University at "Demo" Fayoum Governorate, Egypt during the two successive seasons of 2018/2019 and /2019/2020. The main objective of this study was to determine the effect of cytokinin, yeast extract, zinc and their interaction on growth of wheat (Triticum aestivum L.). The experimental layout was a split- split plot arranged in randomized complete block design with three replications where zinc concentrations (control, 1g/liter, 2g/liter) were considered as the main plot, cytokinin rates (control, 0.25ml/liter, 0.50ml/liter )arranged in the sub plot and the sub-sub plot occupied by yeast extract levels treatments(control, 5g/liter, 10g/liter). Data indicated that zinc concentrations had insignificant effect on the characteristics of number of tillers/plant, number of leaves/plant, plant leaf area, and leaf content of chlorophyllat 100 days from sowing (DAS). While the addition of mid-level of zinc zn₁ (1g/l) led to a significant increase at 70 and 85 DAS. Increasing the cytokinin concentration led to an increase in plant height at 100 DAS in the second season only. As for the number of tillers/plant in both seasons at 85 DAS, but the number of leaves/plant it did not reach the significant level. Cytokinin concentration had no significant effect on leaf area/plant, flag leaf area and leaf content of chlorophyll. Increasing the concentration of yeast extract which foliar application to wheat plants led to a significant increase in the leaf area/plant and leaf content of chlorophyll.