The protective activity of Bee-collected pollen (BPE) and watersoluble derivative of propolis (WSDPE) aqueous extracts was studied
on cisplatin (CDDP) induced genotoxicity in male albino mice (Mus
mascullus). The treatment of mice with Bee-collected pollen and
propolis extracts at doses 140 and 8.4 mg/kg body weight/day,
respectively for 14 days synergistically with the intraperitoneal
administration of cisplatin at dose of 2.8 mg/kg b.wt exhibited
significant chemoprotective activity. Genotoxicity and cytotoxicity
were evaluated by the bone marrow chromosomal aberration assay
and mitotic index, respectively. The animals of positive control group < br />(CDDP alone) showed a significant increase in genotoxicity. WSDPE
and BPE, alone did not significantly induce chromosomal aberrations
confirming their non-mutagenic effects. While, the animals in groups
five and six (G5 and G6), that were injected i.p. with CDDP alone for
one week and then for the next 14 days these animals were given
WSDPE and BPE through oral intubation in synergistic with i.p.
injection of CDDP, exhibited a significant decrease in cytogenetic
damages induced by CDDP in bone marrow cells. The anticytotoxicity effects of WSDPE and BPE were also evident, as
observed by significant increase in mitotic index, when compared to
positive control group (G2). Thus, results of the present investigation
revealed that WSDP and BPE have chemoprotective potentials against
CDDP induced genotoxicity in bone marrow cells of male albino
mice. Also, the present investigation indicated that the
chemoprotective frequency of BPE was much greater than WSDPE.