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197032

ANTIMUTAGENIC ACTIVITY OF BEE POLLEN AND PROPOLIS WATER EXTRACTS AGAINST CISPLATIN-INDUCED CHROMOSOMAL ABNORMALITIES IN BONE MARROW CELLS OF MICE

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Last updated: 05 Jan 2025

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Abstract

The protective activity of Bee-collected pollen (BPE) and watersoluble derivative of propolis (WSDPE) aqueous extracts was studied
on cisplatin (CDDP) induced genotoxicity in male albino mice (Mus
mascullus). The treatment of mice with Bee-collected pollen and
propolis extracts at doses 140 and 8.4 mg/kg body weight/day,
respectively for 14 days synergistically with the intraperitoneal
administration of cisplatin at dose of 2.8 mg/kg b.wt exhibited
significant chemoprotective activity. Genotoxicity and cytotoxicity
were evaluated by the bone marrow chromosomal aberration assay
and mitotic index, respectively. The animals of positive control group < br />(CDDP alone) showed a significant increase in genotoxicity. WSDPE
and BPE, alone did not significantly induce chromosomal aberrations
confirming their non-mutagenic effects. While, the animals in groups
five and six (G5 and G6), that were injected i.p. with CDDP alone for
one week and then for the next 14 days these animals were given
WSDPE and BPE through oral intubation in synergistic with i.p.
injection of CDDP, exhibited a significant decrease in cytogenetic
damages induced by CDDP in bone marrow cells. The anticytotoxicity effects of WSDPE and BPE were also evident, as
observed by significant increase in mitotic index, when compared to
positive control group (G2). Thus, results of the present investigation
revealed that WSDP and BPE have chemoprotective potentials against
CDDP induced genotoxicity in bone marrow cells of male albino
mice. Also, the present investigation indicated that the
chemoprotective frequency of BPE was much greater than WSDPE.

DOI

10.21608/fjard.2009.197032

Keywords

Antimutagen, Albino mice, bee pollen, Propolis

Authors

First Name

Amany A.

Last Name

Tohamy

MiddleName

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Affiliation

Faculty of Science, Zoology Department, Helwan University, Egypt.

Email

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Orcid

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First Name

Ehab M.

Last Name

Abdella

MiddleName

-

Affiliation

Faculty of Science, Zoology Department, Beni-Suef University, Egypt.

Email

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City

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Orcid

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First Name

Rasha R.

Last Name

Ahmad

MiddleName

-

Affiliation

Faculty of Science, Zoology Department, Beni-Suef University, Egypt.

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Orcid

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Volume

23

Article Issue

1

Related Issue

27885

Issue Date

2009-01-01

Receive Date

2021-09-30

Publish Date

2009-01-01

Page Start

1

Page End

12

Print ISSN

1110-7790

Online ISSN

2805-2528

Article File

FJARD_Volume 23_Issue 1_Pages 1-12.pdf

PDF . 428.0kB

Link

https://fjard.journals.ekb.eg/article_197032.html

Detail API

https://fjard.journals.ekb.eg/service?article_code=197032

Order

21

Type

Research articles.

Type Code

1,920

Publication Type

Journal

Publication Title

Fayoum Journal of Agricultural Research and Development

Publication Link

https://fjard.journals.ekb.eg/

MainTitle

ANTIMUTAGENIC ACTIVITY OF BEE POLLEN AND PROPOLIS WATER EXTRACTS AGAINST CISPLATIN-INDUCED CHROMOSOMAL ABNORMALITIES IN BONE MARROW CELLS OF MICE

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Article

Created At

23 Jan 2023