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191254

ANTIOXIDANT, ANTICANCER AND IMMUNOCYTOCHEMISTRY ACTIVITIES OF THREE SYNTHETIC COUMARIN DERIVATIVES

Article

Last updated: 05 Jan 2025

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Subjects

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Tags

Agricultural Economics and Management Sciences

Abstract

Many biological studies have indicated that coumarin and its
derivatives can act as chemoperventive agents. In this study, three synthetic
coumarin derivatives were investigated for their free radical scavenging,
anticancer and cell signaling activities. Compound A showed antioxidant
effects with 100% decoloration of DPPH at concentration of more than 150
µg/ml with IC50 of 102.12 ± 0.15 µg/ml. Compound B and C induced
antioxidant effects with 100% decoloration at 100 and 50 µg/ml,
respectively. Also, the IC50 of compounds B and C was 28.35 ± 0.04 and
6.12 ± 0.05 µg/ml, respectively. Moreover, these compounds suppressed
PC-3 prostate and MDA-MB-453 breast cancer cells proliferation with IC50
of 20 µM, 70 µM and 50 µM, respectively for PC-3 cells. However, it needs
higher dosage to inhibit MDA-MB-453 breast cancer cell growth with IC50
at 25 µM, 137 µM and 100 µM, respectively. All of these compounds
activated the apoptotic death signals downstream by activating caspase
pathway. And showed many apoptotic characterizations including, DNA
fragmentation and apoptotic bodies formation.

DOI

10.21608/fjard.2017.191254

Keywords

antioxidant, Anticancer, free radical scavenging activity, Synthetic coumarin derivatives, apoptosis, Prostate Cancer, breast cancer

Authors

First Name

Amr

Last Name

E. M. Mahmoud

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Agriculture, Fayoum University, Egypt.

Email

-

City

-

Orcid

-

First Name

Fasil

Last Name

A. Abebe

MiddleName

-

Affiliation

Chemistry Department, Morgan State university, USA

Email

-

City

-

Orcid

-

First Name

Ghada

Last Name

O. El-Demerdash

MiddleName

-

Affiliation

Animal Health Research Institute, Agricultural Research Center, Egypt.

Email

-

City

-

Orcid

-

First Name

Ekkehard

Last Name

A. Sinn

MiddleName

-

Affiliation

Chemistry Department, Western Michigan University, USA.

Email

-

City

-

Orcid

-

Volume

31

Article Issue

2

Related Issue

27317

Issue Date

2017-07-01

Receive Date

2021-08-25

Publish Date

2017-07-01

Page Start

79

Page End

94

Print ISSN

1110-7790

Online ISSN

2805-2528

Article File

FJARD_Volume 31_Issue 2_Pages 79-94.pdf

PDF . 2.0MB

Link

https://fjard.journals.ekb.eg/article_191254.html

Detail API

https://fjard.journals.ekb.eg/service?article_code=191254

Order

7

Type

Research articles.

Type Code

1,920

Publication Type

Journal

Publication Title

Fayoum Journal of Agricultural Research and Development

Publication Link

https://fjard.journals.ekb.eg/

MainTitle

ANTIOXIDANT, ANTICANCER AND IMMUNOCYTOCHEMISTRY ACTIVITIES OF THREE SYNTHETIC COUMARIN DERIVATIVES

Details

Type

Article

Created At

23 Jan 2023