Jerusalem artichoke (Helianthus tuberosus L.) is considered as one of noncomparatively new traditional vegetable crop introduced in Egypt. It is considered as one of the primary sources for inulin in higher plants. The scope of the current study was to assess the main and interaction effects of two natural and safety materials; potassium humate as soil application and proline as foliar spraying on growth and productivity of Jerusalem artichoke plants cv. Balady. Therefore, two field experiments were conducted during the summer seasons of 2015 and 2016 in Demo Experimental Farm, Faculty of Agriculture, Fayoum University. The experimental layout was a split- plot system in a Randomized Complete Blocks Design with three replications.Three Potassium humate levels (0, 20, 40 kg fed-1 ) were randomly distributed in the main plots whilst, Three proline concentrations (0, 5, 10 mM) were allocated in the sub-plots. Gained results displayed that tubers weight plant-1 , number of tubers plant-1 , dry weight of tuber plant-1 and yield fed-1 were positively responded to either soil application of potassium humate or foliar spraying of proline. The impact of foliar application with proline on average weight of tuber was not significant in both seasons. Generally treating Jerusalem artichoke plants with potassium humate or proline gave significantly higher leaves and tubers N, P, K and proline contents in both seasons. On the other side, Leaf and tuber Na contents were, truly depressed owe to application of potassium humate or proline. In addition, the interaction of the two studied factors on leaf and tuber Na contents was intrinsic. Finally, the soil application of potassium humate at 20 and/or 40 kg fed-1 integration with foliar application of proline at 5 and/or 10 mM enhanced Yield and yield components and Chemical composition of Jerusalem artichoke under newly reclaimed soil conditions of Fayoum Governorate.