Obesity in adolescents and children has raised to significant levels globally with serious public health consequences. In addition to cardiovascular diseases, childhood obesity predisposes to insulin resistance, type 2 diabetes, hypertension, hyperlipidemia, liver diseases, renal diseases, and reproductive dysfunction. This condition also increases the risk of adult-onset obesity and cardiovascular disease. The aim of this study is to assess some cardiovascular risk factor among Egyptian obese male adolescent subjects and to determine its relation with sex hormone binding globulin (SHBG). The participants of this study will be an Egyptian male adolescent volunteers aged between (12-19) years old and will be were classified according to their Body Mass index (BMI) as control group: apparently healthy non obese, age matched, their BMI is more than 5th percentile to less than the 85th percentile and Group 2: Obese group, their BMI more than 95 percentile. Our result showed that there is negative correlation between Sex Hormone Binding Globulin (SHBG) and Body Mass Index (BMI) which consider a biomarker for metabolic syndrome.