Formulating applied vermicompost in combination with plant and animal compost as a plant nutrient could improve the performance of faba bean cultivars in reclaiming areas. In the present study, agronomical and nutritional quality traits of some faba bean genotypes were evaluated as a response to organic fertilization under sandy soil conditions. Two field trials were carried out under a drip irrigation system in the Desert Experimental Station, Faculty of Agriculture, Cairo University in Wadi El-Natroon, El-Beheira Governorate, Egypt, during two winter seasons, 2018/2019 and 2019 /2020. A split-plot design in randomized complete blocks arrangement, with four replications was used. Main plots were devoted to three cultivars, and sub-plots were allocated to nine treatments (plant compost, chicken manure, and vermicompost combinations). The results indicated that both cultivars and treatments of organic fertilizers showed highly significant mean squares effects for all studied traits. Besides, both years revealed a significant and positive correlation between seed yield per hectare (ha) and other studied traits. The response of faba bean cultivars to plant compost plus vermicompost activated the highest seed yield and its components as compared to all other treatments. In addition, the application of organic amendments achieved the highest values of seed chemical contents. The response of Sakha-1 cultivar to 100 % plant compost attained the highest response of yield, crude protein, ether extract, and amino acid contents. Remarkably, the interaction between Sakha-1 cultivar and 100 % plant compost plus vermicompost achieved the optimal combination, leading to the highest seed yield (3.12 ton/ha). This mixture is recommended to improve faba bean yield and the nutritional quality of seeds under sandy soil conditions.