Two field experiments were conducted at El-Gemmeiza Agricultural Research Station, ARC, Egypt during the two growing seasons of 2019/2020 and 2020/2021 to elucidate the effects of the combined application of mineral and organic fertilizers on some bread wheat cultivars for increasing the yield productivity and improving the soil sustainability. A split plot design in a randomized complete block arrangement was used with three replications. Main plots were allocated to the three bread wheat cultivars (Gemmieza 12, Sakha 95 and Misr 3), and the four combinations of inorganic and organic fertilizer treatments were assigned to the sub plots. The results showed that application of nitrogen and compost sources either alone or in combination had highly significant effects on grain yield and its attributes across the two seasons. The bread wheat cultivar Sakha 95 was significantly superior to the other cultivars in grain yield (3.71 ton fed-1). The three bread wheat cultivars fertilized with 75% of the recommended dose of N plus compost application of 2 ton fed-1 exhibited the highest grain and straw yields. Highly significant and positive correlation coefficients were detected between 1000 kernel weight, grain and straw yield. The results cleared that, application of organic N plus 75 or 50% of the recommend mineral nitrogen dose to the soil reduced the values of soil bulk density and soil pH and increased total porosity, hydraulic conductivity, available NPK, organic matter, NPK-uptake in both grain and straw yield and protein content in grains.