Water deficiency is a very serious problem in Egypt recently. Thus, a two-year study was conducted at Al Gharirah, Esna, Luxor Governorate, Egypt during the two successive season of 2019/2020 and 2020/2021 to study response of twenty bread wheat genotypes to recommended irrigation (12 times, normal at experiment site conditions) and a reduced number of irrigation (6 irrigations, as stressed treatment). The 20 genotypes that included two high yielding cultivars and eighteen promising lines selected form 22nd High Rainfall Wheat Yield Trial (At CIMMYT breeding program). The design used for the experiment randomized complete block design with three replications. The results showed that reduced number of irrigations caused noticeable reduction in days to heading and maturity and reduction in yield and yield components in both growing seasons. Two lines 16 and 18 were the earliest ones and could be used in breeding programs for earliness. Besides, two lines (1 and 2) and two cultivars (Misr 2 and Sids 14) recorded the maximum values for most studied characters, especially, grain yield under stress condition. The interaction between irrigation and bread wheat genotypes was significant for days to heading, maturity and grain yield in the second growing season. Based on the drought tolerance indices of mean productivity (MP), geometric mean of productivity (GMP), stress tolerance index (STI), yield index (YI), harmonic mean (HM) and modified stress tolerance index (MSTI), Misr 2, Sids 14, Lines 1, 2, 4 and 6 were identified as suitable genotypes under well-watered and water deficit conditions. There were obvious differences among genotypes for grain yield under non-stressed and water stressed treatments which reflect high genetic diversity among them that make possible to screen for genotypes tolerant to water deficit. The first cluster aggregated the genotypes that had the highest grain yield and its component.